RETINA PIONEER

Sohan S. Hayreh, MD, PhD, FRCS

1927-2022
Dr. Sohan Hayreh’s research career spanned 6 decades. Photo courtesy University of Iowa Carver College of Medicine.

Sohan Singh Hayreh, MD, PhD, FRCS, was a renowned ophthalmologist, clinician scientist, and professor emeritus of ophthalmology at the University of Iowa Carver College of Medicine. He died on September 29, 2022 at the age of 94.

Dr. Hayreh remained active in research and publishing well into his 90s. He was widely recognized as a pioneer in fluorescein angiography and a leading authority in vascular diseases of the eye and the optic nerve. His ophthalmology career spanned more than 60 years and encompassed basic, experimental, and clinical research.

Dr. Hayreh, an elected fellow of the National Academy of Medical Sciences, published more than 400 original peer-reviewed articles, 6 classical monographs and books, and over 50 book chapters.

In 1973, Dr. Hayreh joined the faculty of the University of Iowa Carver College of Medicine as professor and director of the ocular vascular clinic and ocular vascular research. He assumed emeritus status in 1999 to devote himself full-time to his research.

Dr. Hayreh was born in 1927, the eldest son in a farming family in a remote village in Punjab, India. After he attended local schools, his mother decided he should go to medical school because there were no physicians in the area. He completed his medical training in India and initially wanted to be a general surgeon.

In 1952, Dr. Hayreh joined the Indian Army Medical Corps, working part of the time as a general surgeon to help support his parents and younger brothers and sisters. He served in rough field conditions near the Pakistani border for more than 3 years.

When he had completed his military service, Dr. Hayreh was eager to pursue an academic and research career. “He then accepted in 1955 the only available academic position, which happened to be in the anatomy department of the newly opened Medical College in Patiala in Punjab,” said Jost B. Jonas, MD.

A lack of money for research never daunted him. In 1991, Dr. Hayreh recalled in “Adventure in 3 Worlds,” an article in Survey of Ophthalmology. “With the faintest of hopes, I wrote to the DuPont company asking if they could possibly send me some free samples of liquid latex, and they sent me 2 gallons, which was enough for my project (preparing vascular casts to study the anatomy of the vascular bed in the human). The rest, as they say, is history.”

A turning point in Dr. Hayreh’s career came in 1961, when he was awarded the prestigious Beit Memorial Research Fellowship for Medical Research; he moved to London to work with Sir Stuart Duke-Elder at the Institute of Ophthalmology, University of London. That research formed the basis of his PhD thesis from the University of London in 1965.

Dr. Hayreh then worked as a member of the academic staff of the University of London and the University of Edinburgh before joining the faculty at the University of Iowa Carver College of Medicine.

highlights

1961-1963

Discovered that fenestration of the optic nerve sheath relieved optic disc edema in raised intracranial pressure, an observation that underlies current treatment in idiopathic intracranial hypertension.

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1961-1963

Discovered the two types of central retinal vein occlusion.

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1963

Determined that the blood supply of the optic nerve head is solely by posterior ciliary artery circulation.

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1963

Described vascular insufficiency in the optic nerve head in glaucoma.

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1963

Demonstrated the angiographic pattern of choroidal melanomas and radiation retinopathy.

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1969

Described the strict segmental distribution of the branches of the posterior cerebral arteries and the watershed zones between them, which play important roles in the pathogeneses of choroidal and optic nerve head ischemic disorders.

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1969

Discovered there are no anastomoses in the choroid.

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1969

Showed the lobular vascular pattern of the choriocapillaris with an arteriole in the center and venous channels at the periphery.

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1969

Demonstrated the segmental distribution and watershed zones in various vortex veins.

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1995

Duke-Elder Medal and Lecture of the Royal College of Ophthalmologists, London, England.

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1999

Research to Prevent Blindness Senior Scientific Investigator Award.

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2001

Arnall Patz Medal of the Macula Society for outstanding contributions in the retinal vascular and macular diseases.

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2002

Guest of Honor of the American Academy of Ophthalmology.

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2003

Received the Association for Research in Vision and Ophthalmology’s Mildred Weisenfeld Award for Excellence in Ophthalmology for his contributions to the clinical practice of ophthalmology and vision sciences.

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Work History

1955

  • Anatomy department, Medical College, Patiala, India

1961-1964

  • Beit Memorial Research Fellow in Medical Sciences, University of London

1964-1965

  • Senior house officer, Birmingham & Midland Eye Hospital

1965-1969

  • Lecturer in clinical ophthalmology, Institute of Ophthalmology, University of London

1969-1973

  • Senior lecturer and reader in ophthalmology, University of Edinburgh

1973-1999

  • Professor of Ophthalmology and Director of the Ocular Vascular Division, University of Iowa

1999-2022

  • Professor Emeritus of Ophthalmology and Director of the Ocular Vascular Division, University of Iowa

Education and Training

Fellowship:

Royal College of Surgeons of Edinburgh and Royal College of Surgeons of England

Doctorate of Medicine:

University of London, 1987

Master’s Degree in Surgery:

Punjab University, 1959

Residency:

Punjab University, 1955

Military Service:

Medical Officer in the Indian Army Medical Corp, 1952-1955

Medical School:

Punjab University, 1951

Reflections

Judy E. Kim, MD

Sohan Hayreh was a legend in ophthalmology. His seminal research changed basic concepts about ocular vascular occlusive disorders, glaucoma, and optic nerve disorders and how we manage those conditions. He will always be renowned for challenging established thinking with his sometimes-controversial ideas.

Keith D. Carter, MD

Dr. Sohan Hayreh was an inspirational force in our department. His research had a great impact on our profession, and many patients have benefited from its clinical applications. Dr. Hayreh always challenged us to be inquisitive and push our creative boundaries. He will be missed by our profession and our department. There will not be another Sohan Hayreh.

Joel Pearlman, MD, PhD

We all owe Dr. Hayreh a tremendous debt of gratitude for elucidating so many retinal, choroidal, and optic nerve vascular diseases and for developing the tools for us to study them. He was a true giant in our field. Amazing what a genius can do with 2 gallons of latex from DuPont.

Additional Resources

Retina Times: ASRS Remembers Sohan S. Hayreh, MD, PhD, FRCS (1927-2022) Leading Researcher, Fluorescein Angiography Pioneer

*Please note, Portions of this Tribute were previously published in Retina Times. See article link above.

(Published May 2025)